Syringe Filters

Syringe Filters

Overview

Syringe filters are membrane-based devices designed for rapid filtration of liquid samples directly from a syringe. They consist of a membrane housed in a plastic device, available in various diameters (4mm to 33mm) and pore sizes (0.1µm to 20µm).

How to Choose a Syringe Filter?

Step 1: Select the Membrane Materials

  • Nylon Syringe Filter---Low extractable. Filtration of mixed solvents and solvents, HPCL samples.
  • PES Syringe Filter---High flow rate. Filtration of tissue culture media.
  • PVDF Syringe Filter---Low protein binding. Compatible with protein solutions and mild organic solutions.
  • PTFE Syringe Filter---Maximum chemical resistance. Filtration of mixed solvents and solvents.
  • PP Syringe Filter---Broad range of pore sizes. Prefiltration and solvent filtration.
  • GF Syringe Filter --- Water quality analysis.

Step 2: Choose the Right Pore Sizes

  • 0.1µm: Mycoplasma filtration.
  • 0.22µm: Sterile filtration, bacteria removal.
  • 0.45µm: Particle removal, HPLC sample prep.
  • 0.8–20µm: Prefiltration of viscous samples.

Step 3: Select by Volume

Sample Volume
Filter Diameter Filtration Area Hold-up Volume
< 10mL 13mm 0.72 cm² < 25μL
10mL to 100mL 25mm 3.4 cm² < 100μL
100mL to 200mL 33mm 4.5 cm² < 125μL

Cobetter Syringe Filters are Available in:

  • Color-coded Syringe Filters

Cobetter color-coded syringe filters are ideal for particle removal with a sample volume of 1-200mL.

  • HPLC-certified Syringe Filters(White Premium)

Cobetter white Hydrophilic PTFE syringe filters are HPLC-certified for low levels of UV-absorbing extractable.

  • Sterile Syringe Filters

Cobetter sterile syringe filters are ideal for sterile filtration of cell culture media with a high flow rate and low protein adsorption.

    How to sterilize syringe filters?

    Autoclaving

    Only autoclavable syringe filters can be autoclaved. They can withstand autoclaving at 121°C (up to a maximum of 130°C) for 30 minutes, and this process can be repeated up to 20 times. However, we recommend using it only once for optimal performance after autoclaving. 

    Gamma Irradiation

    Gamma irradiation involves exposing the filters to high-energy gamma rays, which can kill microorganisms such as bacteria, viruses and fungi. This method is typically used for large-scale sterilization in a relatively short time. Cobetter sterile syringe filters are gamma irradiated and individually packed.

    Additionally, be sure to handle the filters with clean gloves or use it in the clean bench to avoid introducing contaminants while using.

    Related Articles

    How to Choose a Syringe Filter?

    Are Syringe Filters Single-use?

    Video
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    • Chemical_Compatibility_Chart_for_Syringe_Filters Download
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    FAQ

    Q1: Can syringe filters be reused?

    No, it is disposable. Once a syringe filter was reused, it would cause contamination risk of the sample.

    Q2: What’s the shelf life of syringe filters?

    Cobetter syringe filter’s shelf life is 3 years.

    Q3: Can you autoclave syringe filters?

    No, it is not recommended.

    Q4: What is the maximum operating temperature of syringe filters?

    The maximum recommended operating temperature is 60°C.

    Q5: Why should I use a syringe filter that has a prefilter layer?

    The prefilter layer can reduce particle loading. Applications containing high levels of particulates need syringe filters with multiple layers of membrane, which usually have greater total throughput when compared with single-layer ones.