Virus filtration is a robust virus clearance method in the production process of common biopharmaceutical products. Due to its simple and gentle operation, clear mechanism, and ease of validation, it has been widely used to ensure biological products' virus safety.
The Viruclear RC series has a nominal pore size of 20 nm. Based on a size exclusion mechanism, it can effectively remove a variety of viral particles, including parvoviruses.
Cobetter's new Viruclear RC series virus removal filters, made from regenerated cellulose, are specifically designed for difficult-to-filter protein solution. The natural excellent hydrophilicity of regenerated cellulose makes it have lower adsorption, higher protein recovery rate, and better filterability in complex liquids containing hydrophobic proteins, aggregates and other impurities.
The Viruclear RC series will serve as another solution to address the underperforming projects of the Viruclear VF plus series. It is particularly suitable for biological products from human plasma, providing customers with a more comprehensive virus filtration solution.
The Vrudear RC series can be provided in the form of silicone cassette containing preservation solution, and rigid plastic cassette wth pure water package. The rigid plastic cassette is shipped with sterile package. Customers may choose according to their own applications.
Viruclear RC H
RC Material Virus Removal Filter Suitable for High-Concentration Feed Solutions
Featuring a robust regenerated cellulose (RC) membrane, the newly launched RC H series provides improved structural stability, maintaining consistent pore size and flow channels during constant pressure filtration. The RC H filter enables higher process fluxes with high-concentration protein solutions and offers increased protein mass capacity for complex feed streams, all while providing robust virus removal. This filter finds particular application in the virus clearance step for blood products, such as high-concentration Intravenous Immunoglobulin (MIG).
Features
- RC membrane has natural excellent hydrophilic properties providing virus removal membrane with low adsorption and high yield
- Asymmetric membrane structure and pre-filtration layer on the upper surface give the membrane excellent anti-fouling performance
- The narrow pore size distribution of the selective layer gives the membrane good separation performance
- Robust virus removal capabilities
- Chemically stable
- Ease of installation, filtration and integrity test
Applications
- Coagulation factors
- Immunoglobulin
- Biochemicalextract
- Fusion protein
- Antibodies
