Purcise™ Q Membrane Chromatography Syringe Filter
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Purcise™ Q Membrane is a novel anion exchange medium that modifies specific functional groups in a crosslinked polymer coating to achieve the separation and purification of negatively charged components.
Purcise™ Q membrane adsorber (chromatography) medium features sufficiently large pore channels that allow larger biomolecules to pass through, while enabling convective mass transfer on the channel surfaces, thus facilitating rapid binding of target molecules to ligand sites. Compared to traditional column chromatography media, membrane adsorber (chromatography) media offer higher process flow rates to shorten processing times and possess higher dynamic binding capacities for biomolecules (such as plasmid DNA, enveloped viruses, host cell proteins, etc.), thereby reducing process costs.
Specifications
| Physical Properties |
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| Volume |
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| Minimum standard BSA binding capacity |
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| Layers |
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| Connections |
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| Recommended Flow Rate Range* |
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| Operating Conditions | Membrane | PES | |||
| Membrane Configuration | Flat sheet | ||||
| Housing | PP | ||||
| Nominal Pore size | 0.7μm | ||||
| Max. Operation Pressure | 4.0 bar | ||||
| Pre-use Storage Condition | Storage at room Temperature or 2~8°C | ||||
| Post-use Storage Solution | 0.1M NaOH | ||||
| Functional Group | Mixed amino group | ||||
| Package | Pack Size | 1 or 4 pcs/pk |
* Recommended flow rates are based on 1-25 film volumes/min. Actual process flow rates will be determined based on process requirements, maximum back pressure, and process time.
Features
- High Binding Efficiency
Membrane chromatography media have large enough pore channels to exhibit high loading at low pressure drop as well as high flow rates. Membrane chromatography media are based on the principle of convective mass transfer, which allows charged biomolecules to be bound in a single pass through the membrane, making it less dependent on retention time.
- High Flow Rates
Membrane chromatography media are recommended for operating flow rates of 10 MV/min within pressure limits (9 ml/min for 0.9 ml membranes), resulting in 30 to 50 times faster productivity with membrane chromatography than with traditional packed chromatography.
- Scalability and Flexibility
A full range of membrane chromatography media is available to meet the volume and performance needs of the biopharmaceutical industry, from process development to the largest scale of production. Membrane chromatography media can be single-use or cleaned and reused.
- Reproducible
The full range of membrane chromatography media is manufactured to strict ISO 9000 standards to ensure reproducible processes, conformity to specifications and consistent performance.
- Low Cost
Membrane chromatography media are less expensive to operate (e.g. less buffer, less time investment, etc.) and less capital intensive (e.g. no additional hardware investment required, etc.) than conventional columns that require efficient loading and cleaning programmes.
- Easy to Use
The easy-to-use filter format requires only a simple connection for immediate use, eliminating the need for column loading. If the product is single-use, there is even no cleaning.
Applications
- Removal of contaminants such as host DNA, viruses, host cell proteins and endotoxins from biological fluids.
- Capture of relatively large target molecules (e.g. recombinant proteins, plasmids, viral vectors and plasma fractions).
- Purification of small molecules such as oligonucleotides, peptides.
- Purcise_Q_Strong_Anion_Exchange_Membrane_Chromatography Download