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Purcise™ MEC 0.1 μm PES Bricap T Capsule Filter for Mycoplasma Removal

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Part No. T10SSNMECBA1P
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*Not for medical use

Bricap™ T-style capsule filters are designed for large-scale production with robust construction and high flow rates. They are available in three filtration area options: 0.55 m², 1.1 m², 1.65 m².

Purcise™ MEC 0.1 μm features an advanced double-layer hydrophilic PES membrane specifically designed for cell culture media mycoplasma filtration applications. The membrane combines low cytotoxicity and low adsorption characteristics to minimize the loss of critical media components while maintaining excellent cell compatibility.

Features

  • Double Layer Hydrophilic Polyethersulfone (PES) Membrane: 0.2 μm pre-filter + 0.1 μm final filter membrane. Reliable retention of mycoplasma, bacteria and particles. Low cytotoxicity. Low adsorption
  • Sterilizing -grade Filter: Bacterial Retention validated according to ASTM F838, each filter is integrity tested prior to release
  • Linear Scale Up: Available in syringe filter for filterability study, small-scale capsule filter for process development, and large-scale capusle filter and filter cartridge for commercial GMP manufacturing.

Applications

  • Mycoplasma filtration of culture media

Quality Standards

  • ISO 9001: 2015 Quality Management System
  • Manufactured for use in conformance with cGMP
  • Each product is integrity tested prior to release
  • Unique serial number for full traceability
  • COA/COQ provided with shipment
  • Validation documents are available upon request
Physical Properties Filter Format Bricap™ T Capsule Filter
Scale Production Scale
Filter Size 0.55 m², 1.1 m², 1.65 m²
Pore Size 0.1 μm (final-filter)
Pre-filter 0.2 μm
Bubble Point (per 0.55 m²） ≥0.27 MPa at 20 °C, air, wetted with water
Air Diffusion (per 0.55 m²） ≤30 mL/min at 0.35 MPa at 20 °C, wetted with water
Materials Membrane Material Polyethersulfone (PES)
Support Fleece Polypropylene (PP)
Housing Polypropylene (PP)
O-ring / Seal Silicone
Operating Conditions Max. Differential Pressure (Forward) 0.55 MPa at 25 °C, 0.1 MPa at 80 °C
Max. Differential Pressure (Reverse) 0.21 MPa at 25 °C
Max. Operating Temperature 80 °C
Regulatory Compliance Compliance USP <788> Particulate Matter
USP <87> Cytotoxicity
USP <88> Biological Reactivity
FDA Indirect Food Additives, 21 CFR 177-182
ADCF Materials
Bacterial Retention 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) according to ASTM F838
Bacterial Endotoxin Endotoxin Limit of WFI System<0.25 EU/mL with the Limulus Amebocyte Lysate (LAL), USP <85>
Non-Fiber Releasing The products meet the criteria as defined in 21 CFR 210.3(b)(6)
Sterility Sterilization Method Autoclavable: 25 cycles for 30 min @130°C (SIP not compatible)

Gamma Compatible: can be sterilized by gamma irradiation or be autoclaved 5 cycles for 60 min @126°C

Pre-sterilized: by gamma irradiation at 25–45 kGy

Pre-sterilized: by autoclaved packed in cleansteam bag
Package Pack Size Pack of 1
Packaging Individually packed in a double PE bag