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50 L Lifecask™ RG Single-Use Bioreactor Bags

In stock
Part No. KRG50LS2L30
Size
Distribution Ratio (Macro:Micro)
Macro Sparger (integrated together with 20μm Micro Sparger)
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*Not for medical use

Cobetter Lifecask™ RG single-use bioreactor bags aim to offer a reliable upstream process solution for bio-pharmaceutical companies. The scale ranges from 50L to 2000L, covering the requirements from lab to manufacturing process. Our unique, patented split aeration disk design has been confirmed to satisfy the oxygen requirement at each scale.

Comparing with stainless steel system, the use of Lifecask™ RG single-use bioreactor bags is free from complex and time-consuming SIP and CIP, which makes them an easier and more time-saving solution for upstream process. The RG bioreactor bags are made of our own Lifemeta™ KA film, which features low extractables and good mechanical performance, which makes them ideal for cell culture. Multiple kinds of tubings and ports are designed to satisfy each single stage of cell culture, including probe installation, cell inoculation, sampling, feeding, and harvesting. Single-use pressure sensor and back-up filter port are designed to minimize the risk of bag breakage, thus guarantee safe running of the cell culture process.

Features

  • Patented self-developed sparger
  • Fully in-house manufactured components
  • Robust scalability data accelerating the path from R&D to commercial manufacturing
  • Comprehensive validation documentation ensures a robust process workflow
  • High-standard quality management system and safe supply chain

Applications

Lifecask™ RG single-use bioreactor bags can be applied to multiple fields (antibody, vaccine and CGT, etc.) and different kinds of cell culture process such as suspension cell culture (CHO, HEK293, BHK21, Hybridoma or SF9, etc.) and adherent cell culture (Vero, HEK293T, hMSC, etc.). Our single-use bioreactor bags are available in multiple sizes and configurations and can be customized to satisfy the requirements of special process such as high CO₂ stripping, low shear stress and high cell density cell culture.

Quality Standards

  • ISO 9001: 2015 Quality Management System
  • ISO 7 cleanroom production
  • Manufactured for use in conformance with cGMP
  • Each product is integrity tested prior to release
  • COA/COQ provided with shipment
  • Validation documents are available upon request
  • TSE/BSE certificate available
Physical Properties Product Name Lifecask™ RG Bioreactor Bag
Bag Volume 50 L
Max. Working Volume 50 L
Min. Working Volume 22 L
Turn-down Ratio 2.2 : 1
Aspect Ratio (H/D) 2.25 : 1
Filter Type with Vent Filter
Materials Film Material Lifemeta™ KA film
Configurations Exhaust Line with Bricap™ Vent Filter
Sparger Pore sizes of aeration hole: 20 μm, 0.5 mm, 1 mm
Number of Sensors 1 pH sensor, 1 DO Sensor
Thermowell Yes
Regulatory Compliance Compliance USP <788> Particulate Matter
USP <87> Cytotoxicity
USP <88> Biological Reactivity
FDA Indirect Food Additives, 21 CFR 177-182
ADCF Materials
Bacterial Endotoxin Endotoxin Limit of WFI System<0.25 EU/mL with the Limulus Amebocyte Lysate (LAL), USP <85>
Sterility Delivery Condition Sterile
Sterilization Method Gamma irradiation at 25–45 kGy
Package Pack Size Pack of 1
Packaging Individually packed in double PE bag


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