Consieve UET Ultrafiltration Cassettes PES Membrane Pilot
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Consieve UET tangential flow filtration cassette is made of asymmetric mPES (modified Polyethersulfone) membrane, which provides high flow rate, low protein bindings and wide pH compatibility. The cassette is easy to clean, install and has a high retention efficiency, with low working volume and high efficiency which ensures product yields.
Consieve UET Ultrafiltration TFF cassettes are available in a wide range of molecular weight cut-offs from 5 kDa to 750 kDa. It can be easily scale-up from Lab, Pilot to Process scale with a wide volume range from 0.5L to 20,000L. They are widely used in separation, concentration and diafiltration in downstream bioprocessing.
The cassettes should be used with Cobetter Ultrafiltration Cassette Stainless Steel Holder:
EFA 0.01m² cassettes use with Ultrafiltration Cassette Holders (0.01m²)
EFA 0.11m² cassettes use with Ultrafiltration Cassette Holders (0.11m²)
EFA 0.46m²or 2.33m²cassettes use with Ultrafiltration Cassette Holders (0.5m²)
Specifications
| Materials | Membrane material | mPES |
| Screen | PP | |
| Seals(internal) | Silicone | |
| Encapsulant | White polyurethane Silicone | |
| Gaskets | Platinum cured silicone | |
| Physical Properties | MWCO | 1/3/5/8/10/30/50/100/300/500/1000 kDa |
| Throughput | >50L | |
| Dead Volume | 50mL | |
| Pressure Drop | 0.3-0.6 bar (Circulation Flow Rate 6L/min/m²) | |
| Effective Filtration Area | 0.46 m² (5 ft²) | |
| Diffusion Flow @0.1Mpa | ≤50 mL/min | |
| Corssflow rate @0.2Mpa | 3.5-7 L/min | |
| Operating Conditions | Operating Temperature Range | 4-50°C |
| Max. Operating Pressure | 6.0 bar @ 25 °C | |
| pH range | 1.0-14.0 | |
| Sterility | Delivery Condition |
Nonsterile |
| Package | Pack Size | 1pcs |
| Packaging | Individually packed in PE bag |
Screen Difference
| Screen Type | Flow Resistance | Flow Rate (LMM@dp 15psi Water) | Applications |
| Tight Screen | High | 5~6 | Generates the strongest turbulence on the membrane surface. Tight Screen can achieve relatively high tangential flow velocity at a relatively low inlet flow rate, but has a high pressure drop (dp) and is easily clogged by particles. Tight screen cassettes are suitable for samples without particles, low viscosity, and low concentration. |
| Standard Coarse Screen | Medium | 8~11 | Generates moderate turbulence on the membrane surface, reducing clogging. Standard Coarse Screen requires a higher inlet flow rate to match the appropriate tangential flow velocity. The pressure drop (dp) is significantly lower compared to Tight Screens. Standard coarse screen cassettes are suitable for clarified samples with medium to high viscosity. |
| Suspended Screen | Low | ≥40 | Generates the weakest turbulence and low shear force on the surface, but still significantly reduces clogging. Theoretically, Suspended Screen requires a very high inlet flow rate. Due to its open screen structure, it can accommodate more particles (cells, cell debris) without clogging. Suspended screen cassettes are suitable for unclarified samples with high particle content or high viscosity, and samples that are sensitive to shear force. |
Features
- High flow rate
- Low protein binding
- High product yield
- No glue used, resulting in low extractables
- pH range: 1-14
Applications
- Concentration and desalting of proteins, peptides or nucleic acids
- Buffer exchange
- Fractionation and purification
- Sample preparation before chromatography
- Remove pyrogens from water, buffers, media solutions
Retention Rate
Check the TFF cassette retention rate diagram as shown below.
- COBETTER_Consieve_TFF_Cassettes_and_Systems_20240927 Download