Lifecube™ S-M Single-Use Buffer Preparation System
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Cobetter LifecubeTM S-M single-use buffer preparation system consists of stainless steel support vessel, magnetic stirring drive motor and automatic control system. The buffer preparation system is designed with all high-precision accessories, which can provide a variety of stirring and mixing operation processes for liquid-liquid and powder-liquid mixing in biopharmaceutical process.
The automation system meets the requirements of 21 CFR Part 11 and can realize three-level authority configuration, online instrument calibration, batch report printing, alarm records and other audit trail functions, fully meeting the requirements of data integrity and reliability. The control unit is highly integrated and can be used offline as well. Data upload and integration can be achieved through the customer's central control system. The configured HMI/IPC control interface can realize pH detection, conductivity detection, temperature detection, dissolved oxygen detection and other data.
The system can be configured with integral and split stirring motors, and up/down stirring modes can be selected as needed. From 20L to 2000L, Cobetter can provide customized services according to customers' production scale requirements. The mixing bag is pre-sterilized and requires no cleaning. Users can observe the mixing conditions inside the mixing bag through the system's viewing window.
Specifications
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Parameters
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Description
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Main body material
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304 stainless steel
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Surface treatment
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Internal and external shot blasting Ra≤1.0μm
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Casters
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Polyurethane casters for clean area, can be moved flexibly
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Stirring motor
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Magnetic coupling stirring/magnetic levitation stirring, can be equipped with servo drive for speed adjustment
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Load cell
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Load module adopts C3 grade
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Online temperature (optional)
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Monitor liquid temperature in real time, plug-in/non-plug-in temperature sensor, 4-20mA output, accuracy: ± 0.1°C
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Online pH (optional)
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Monitor PH of liquid in real time, range 0-14
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Online conductivity (optional)
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Monitoring of liquid conductivity in real time, range 1us-300ms/cm
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Online dissolved oxygen (optional)
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Monitor of liquid dissolved oxygen in real time, range 4ppb-25ppm
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Self-control
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User data output, audit trail, PDF report, user rights management
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Jacket
(optional insulation system)
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Three layers and five sides of honeycomb jacket design, test pressure 4 bar, the outside of the insulation
cotton can prevent condensate seepage
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TCU
(optional insulation system)
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Temperature control range 2 to 40°C, Heating and cooling time: 30-120 min
Water temperature control accuracy: within ±0.2°C
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Features
- Can be customized for customers to meet various process requirements
- Up/down stirring and integrated/split stirring modes are available
- With multi-level electronic control system in compliance with cGMP standards, meeting the data integrity and reliability requirements in audit trail
- Can be customized to equip different kinds of instruments and meters to meet the complex monitoring requirements in different processes
- Jacket and the thermal insulation layer is optional, can realize temperature control
- No need for process cleaning between equipment use, simplify cleaning process validation work and improve production efficiency
- Customer-centric concept, provides full range of customized design for customers
- Adopt a stringent quality management system in the industry to ensure the safety, stability and reliability of each product
Applications
- Culture medium preparation
- Buffer preparation
- Dilution preparation
- Intermediates preparation
- Virus inactivation
- Mixing of vaccine adjuvant
- Purification intermediate product mixing process