Pultrix™ XQ Membrane Chromatography Pilot Filter
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Pultrix™ XQ membrane adsorber is an innovative strong anion exchange ligand based on membrane technology. It utilizes a crosslinked polymer coating functionalized with high-density quaternary ammonium (Q) groups to facilitate the capture and purification of negatively charged biomolecules.
Pultrix™ XQ membrane adsorber features a highly interconnected membrane structure (2 μm nominal pore size) and a high density of quaternary ammonium ligands, delivering a large surface area and excellent accessibility for the capture of DNA, proteins, and other large biomolecules. Its open-channel design enables convective flow, ensuring rapid and efficient binding of target molecules. Compared to traditional chromatography resins, XQ membranes support significantly higher flow rate and offer superior dynamic binding capacity for large entities such as host cell DNA, plasmid DNA, host cell proteins, and enveloped viruses — reducing process time and achieve cost reduction effect.
Specifications
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| Volume |
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| Minimum standard BSA binding capacity |
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| Layers |
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| Connections |
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| Recommended Flow Rate Range* |
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| Operating Conditions | Membrane | Polypropylene (PP) | ||||
| Membrane Configuration | Capsule-type radial flow | |||||
| Housing | PP | |||||
| Nominal Pore size | 2 μm | |||||
| Max. Operation Pressure | 3.0 bar | |||||
| Storage Condition | Room Temperature (Before Use) | |||||
| Storage Solution | 0.1M NaOH (After Use) | |||||
| Functional Group | Quaternary Ammonium (Q) | |||||
| Package | Pack Size | 1 pcs/pk |
* Recommended flow rates are based on 1-25 film volumes/min. Actual process flow rates will be determined based on process requirements, maximum back pressure, and process time.
Features
- High Binding Efficiency
Membrane adsorber possess sufficiently large pore channels, enabling high binding capacity and high flow rates even at low pressure drop.
Based on convective mass transfer transport, membrane chromatography allows charged biomolecules to bind as they pass through the membrane in a single pass, eliminating retention time.
- Effective Production
The recommended operating flow rate for membrane adsorber within the pressure limit is 10 MV/min (for a 2.5 mL membrane, a flow rate of 25 mL/min is recommended). Compared to traditional chromatography columns, membrane adsorber can increase production efficiency by 30 to 50 times.
- Scalability and Flexibility
The full range of membrane adsorber is designed to meet diverse volume and performance requirements across the biopharmaceutical industry from processdevelopment to commercial manufacturing. Membrane adsorber can be used as single-use components or reused after validated cleaning procedures.
- High Reproducibility
The entire range of membrane adsorber is manufactured in strict accordance with ISO 9001:2015 standards to ensure process reproducibility, consistency with product specifications, and stable performance.
- Cost-saving Solutioin
Compared to traditional columns that require efficient packing and cleaning protocols, membrane adsorber offer lower operational costs (e.g., reduced buffer consumption, less time investment) and lower capital investment (e.g., no need for additional hardware).
- Ready to Use
The user-friendly filter format requires only simple connections, enabling plug-and-play operation without the need for column packing. For single-use products, there is no need for cleaning validation, cleaning efficiency assessment, or concerns about cross-contamination.
Applications
- Plasmid capture from lysate (integrated lysate concentration/buffer exchange, size exclusion, and anion exchange – as in traditional plasmid purification)
- Purification of biological fluids through the removal of host-derived DNA, viruses, host cell proteins (HCPs), and endotoxins
- Designed for the capture large biomolecular targets such as recombinant proteins, plasmids, viral vectors, and plasma constituents
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