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APSEA Asymmetric PES Filter Cartridge φ69mm, Bioburden Reduction

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Part No. APSEA0022HSCG10SP
Filter Size
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*Not for medical use

APSEA filter cartridges feature a dual-layer membrane configuration combining a polypropylene (PP) prefiltration layer with an asymmetric PES membrane for effective bioburden reduction during manufacturing processes. The PP layer removes larger particles and contaminants, while the asymmetric PES membrane provides reliable microbial retention with an LRV/cm² > 6. With high loading capacity and extended service life, APSEA filters help reduce filtration costs, minimize filter replacement frequency, and ensure robust process performance for biopharmaceutical applications.

Features

  • Excellent long life and cost-effective
  • Asymmetric, high loading capacity, bacterial reduction pre-filtration

Applications

  • Bacterial reduction before final sterilization and filtration
  • Reduces bioburden

Quality Standards

  • ISO 9001: 2015 Quality Management System
  • Manufactured for use in conformance with cGMP
  • Each product is integrity tested prior to release
  • Unique serial number for full traceability
  • COA/COQ provided with shipment
  • Validation documents are available upon request
Physical Properties Filter Format Cartridge Filter
Scale Production Scale
Filtration Area 0.66 m² per 10"
Pore Size 0.22/0.45/0.65/0.8/1.0/1.2/3.0/5.0 μm
Bubble Point

0.22 μm: ≥0.11 MPa at 20 °C, water wetted, air

0.45 μm: ≥0.07 MPa at 20 °C, water wetted, air

0.65 μm: ≥0.04 MPa at 20 °C, water wetted, air
Materials Membrane Material Polyethersulfone (PES)
Support Fleece Polypropylene (PP)
Housing Polypropylene (PP)
O-ring / Seal Silicone
Operating Conditions Max. Differential Pressure (Forward) 0.69 MPa at 25 °C
0.4 MPa at 60 °C
0.24 MPa at 80 °C
Max. Differential Pressure (Reverse) 0.3 MPa at 25 °C
0.1 MPa at 80 °C
Regulatory Compliance Compliance USP <788> Particulate Matter
USP <87> Cytotoxicity
USP <88> Biological Reactivity
FDA Indirect Food Additives, 21 CFR 177-182
ADCF Materials
Bacterial Retention 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) according to ASTM F838
Bacterial Endotoxin Endotoxin Limit of WFI System<0.25 EU/mL with the Limulus Amebocyte Lysate (LAL), USP <85>
Non-Fiber Releasing The products meet the criteria as defined in 21 CFR 210.3(b)(6)
Sterility Delivery Condition Non-sterile
Sterilization Method Can be SIP for 30 min at 135 °C 100 cycles (<30kPa)

Can be autoclaved 200 cycles for 30 min at 130 °C
Package Pack Size Pack of 1
Packaging Individually packed in a double PE bag

 
What are the main applications of prefiltration products?

Prefilters are primarily used to reduce microbial bioburden and enhance the capacity of sterilizing/virus removal filters.

What materials are primarily used for Cobetter prefiltration products?

Cobetter prefilters are primarily made of PES and PVDF, with PP and GF options available for coarse prefiltration or feed clarification.

What are the main pore sizes available for Cobetter prefiltration membranes?

Cobetter prefilters are available in pore sizes of 0.2 µm, 0.45 µm, 0.65 µm, 0.8 µm, and 1.2 µm, etc.