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22 L Lifecask™ RW Single-Use Bioreactor Bags

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Part No. KRW22LVNN1002
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*Not for medical use

Cobetter Lifecask™ RW Single-Use Bioreactor Bags are specially designed for a rocking mode bioreactor. It is sterilized by gamma irradiation and packaged in double PE bag to avoid cross-contamination. The bioreactor bags are manufactured with our self-produced Lifemeta™ KA film or Topene™ RB film to ensure a good mechanical performance as well as biocompatibility.

Lifecask™ RW Single-use Bioreactor bags can be widely applied to multiple upstream process of bio-pharmaceuticals such as antibody, vaccine and CGT. Apart from the Basic bag configuration, we have launched Pro featuring integrated pH and DO optical sensors while RW Perfusion incorporates both pH /DO optical sensors and a integrated retention membrane to satisfy multiple culture modes such as seed train expansion, fed-batch or perfusion processes. What's more, fabric carriers or microcarriers can also be applied to the bags for adherent cell culture.

Features

  • Made of Cobetter self-produced Lifemeta™ KA film or Topene™ RB film to meet the high mechanical strength required by a rocking-mode bioreactor
  • Highly in-house manufactured components with a fully covered equipment portfolio
  • Comprehensive validation documentation ensures a robust process workflow
  • Flexible customization services and stable supply chain

Applications

  • Suspension Cell Culture: CHO, HEK293, BHK21, Hybridoma, SF9
  • Suspension cell perfusion culture (Cell Retention Membrane)
  • Adherent cell culture: HEK 293, Vero, etc.

Quality Standards

  • ISO 9001: 2015 Quality Management System
  • ISO 7 class 7 manufacturing site
  • Manufactured for use in conformance with cGMP
  • Each product is integrity tested prior to release
  • COA/COQ provided with shipment
  • Validation documents are available upon request
  • TSE/BSE certificate available
Physical Properties Product Name Lifecask™ RW Bioreactor Bag
Bag Volume 22 L
Max. Working Volume 11 L
Min. Working Volume 2.2 L
Dimentions LxW: 362 * 716 mm
Perfusion Membrane Size (optional) LxW: 170 * 350 mm
Perfusion Membrane Pore Size (optional)* 7 μm /1.2 μm
Materials Film Material Lifemeta™ KA /Topene™ RB film
Configurations Basic Type Number of Lines: 5
Pro Type Number of Lines: 10 (with optical pH sensor and optical DO sensor)
Perfusion Type Number of Lines: 11 (with optical pH sensor, optical DO sensor, and cell retention membrane)
Regulatory Compliance Compliance USP <788> Particulate Matter
USP <87> Cytotoxicity
USP <88> Biological Reactivity
FDA Indirect Food Additives, 21 CFR 177-182
ADCF Materials
Bacterial Endotoxin Endotoxin Limit of WFI System<0.25 EU/mL with the Limulus Amebocyte Lysate (LAL), USP <85>
Sterility Delivery Condition Sterile
Sterilization Method Gamma irradiation at 25–45 kGy
Package Pack Size Pack of 1
Packaging Individually packed in double PE bag

NOTE: Cobetter supports on-demand customization of 200 L bioreactor bags. For further information, please contact us. 

*The Perfusion cell retention membranes are supplied with a standard 7 µm pore size (standard Part NOs.), offering reliable and consistent performance. For more demanding separation applications, Cobetter also supports customized pore sizes down to 1.2 µm. Please consult our sales representatives prior to placing your order, and we will tailor the optimal configuration to meet your specific needs.

DO Sensor Parameter

Parameter Specification
Range of Measurement 0 - 100% O₂
Resolution ±0.01% O₂ at 0.21% O₂
±0.1% O₂ at 20.9% O₂
Accuracy* ±0.05% O₂ at 0.2% O₂
±0.4% O₂ at 20.9% O₂

NOTE: *Accuracy specifications are derived from a two-point calibration (zero-O₂, and air-saturation).

pH Sensor Parameter

Parameter Specification
Range of Measurement 5.5 - 8.5 pH
Resolution at pH=7 ±0.01 pH
Accuracy at pH=7 ±0.05 pH sensor spot calibration
±0.10 pH sensor batch calibration
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